Table 1. Median Potency Values (IC50) for Growth Inhibition of the Indicated Human Cancer Cell Lines by 968 (First Column) or MDC (Second Column) and the Maximum Observed Cell Growth Inhibition Obtained for Either Inhibitor (Third/Fourth Columns).
IC50 (μM) |
max inhibition of growth (%) |
|||
---|---|---|---|---|
cell line | 968 | MDC | 968 (30 μM) | MDC (120 μM) |
MDA-MB-231 | 4.2 | 60 | 103 | 83 |
Mia-PaCa-2 | 6.7 | 50 | 92 | 97 |
CAMA1 | 15 | 70 | 76 | 102 |
SK-BR-3 | 5.8 | 50 | 109 | 95 |
MCF-7 | 12 | 52 | 80 | 66 |
U-87 MG | 4.2 | 100 | 88 | 52 |
LN-229 | 6.4 | 66 | 77 | 93 |
T98G | 3.8 | >120 | 93 | 17 |