Figure 5.

1-PDT demonstrated significant and prolonged accumulation in tumor tissue for up to 6 h and cleared from the body 72 h postadministration. 4T1-tumor bearing female Balb/c mice were treated at 10 mg/kg via the tail vein. Mice (n = 3) were sacrificed at 0, 0.25, 1, 3, 6, 24, 48, 72 h. (A) Organs and tissues (tumor, draining lymph nodes, spleen, kidney, liver, lung, skin, and eye) were harvested, and (B) fluorescence intensities in each organ were imaged using an in vivo imager (data represent mean ± SEM of three mice at each time point). * p < 0.05; ** p < 0.01; for 1-PDT vs 2-PDT.