Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic illustration of the nucleation mechanism for COM in the presence of phosphate at biological conditions. (a) ACP–ACO coaggregates form as small amorphous Ca–Ox clusters aggregate around large ACP spheres early in the induction period, (b) ACP surface promotes ACO aggregation, (c) multiple prenuclei form within ACO clusters, (d) a composite of multiple COM crystals forms, and (e) a kidney stone containing Ca–P crystals is formed by the confined phase transition of ACP.
