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. 2014 Nov 24;49(1):616–625. doi: 10.1021/es504766p

Figure 3.

Figure 3

Comparison of the levels of (A) 5-136, (B) 4-136, and (C) 4,5-136 in tissues and excreta from female mice with defective hepatic metabolism (KO mice) and their age-matched congenic wild type mice (WT). PCB 136 is primarily eliminated as 5-136, and to a lesser extent as (B) 4-136 and (C) 4,5-136, in the feces of KO and WT mice; however, the time course of fecal HO-PCB metabolite and/or conjugate levels differ significantly between KO and WT mice. Data represent the mean ± standard deviation of the HO-PCB metabolites levels determined in the tissues and excreta of individual, PCB l36-treated KO (n = 7) and WT mice (n = 5) and are expressed on a logarithmic scale as percent of the total PCB 136 dose (see Table S11 for additional details). * Significantly different from WT (t test, p < 0.05); $ different from WT (t test, 0.05 ≤ p < 0.1); nd, not detected.