Figure 4.

Treatment with β-glucuronidase/sulfatase significantly increased the levels of 5-136 and 4,5-136 in day 1 urine from (A) female wild type (WT) mice and (B) female mice with a liver-specific deletion of the cpr gene (KO), suggesting the presence of glucuronide and/or sulfate conjugates of both HO-PCBs in urine. Data represent the mean ± standard error of the mean of the HO-PCB metabolites levels determined in urine from individual, PCB l36-treated mice. *Significantly higher HO-PCB levels following deconjugation (t test, p < 0.05); ^# significantly higher 4,5-136 levels following deconjugation in WT mice compared to KO mice (t test, p < 0.05); nd, not detected.