Skip to main content
. 2014 Nov 24;49(1):616–625. doi: 10.1021/es504766p

Figure 5.

Figure 5

Comparison of the enantiomeric fractions (EFs) of PCB 136 (A), 5-136 (B), and 4-136 (C) in tissues and feces reveals significant differences in the atropisomeric enrichment between female mice with a liver-specific deletion of the cpr gene (KO) and congenic wild type (WT) mice. The EF values are presented as the mean ± standard deviation and were determined in the tissues of individual PCB l36-treated KO (n = 7) and WT mice (n = 5). The only exceptions are the EF determination for 5-136 in blood, which were performed with a single sample pooled by genotype. A CB column was used to separated PCB 136 and 4-136, whereas a BDM column was used for separation of 5-136 (see Table S12 for additional details). * Significantly different from WT (t test, p < 0.05); $ different from WT (t test, 0.05 ≤ p < 0.1); nd, not detected; the dotted line indicates the EF values of the respective racemic standard.