. 2014 Aug 8;2(4):e944449. doi: 10.4161/21688362.2014.944449

Table 5.

Examples of CNS-directed delivery achieved by pathogenic strategies

Ligand	Pathogen	Entry	Payload	Vehicle
Rabies Virus Glyocprotein (RVG)	Rabies Virus	nAchR, P75, NCAM, GABA; presumed direct passage across the BBB; retrograde transport is possible	Nucleic Acids⁷⁹^, ^138-140 Proteins^141,142 Small Molecules¹⁴³	Exosomes¹³⁹ Particles¹⁴³ PEI¹⁴⁰ Dendrimers¹³⁴^,¹⁴⁴ Other⁷⁹^,¹⁴²
Chlorotoxin (CTX)	Scorpion Venom (Leiurus quinquestriatus)	Cl^- channels and MMP-2; presumed direct passage across the BBB	Nucleic Acids^83-88 Proteins⁸⁹ Small Molecules⁸⁸^, ^90-103 Quantum Dots¹⁰⁴ Other¹⁰⁵	Particles⁸⁵^,⁸⁷^, ^{89, 90}^, ^{95, 96}^, ¹⁰¹^,¹⁰³ Lipids⁸³^,⁹¹^, ⁹²^,⁹⁴ DGL⁹³ Dendrimers⁸⁴ PEG⁸⁸^, ^98-101 PEI⁸⁶^,⁸⁸
Dendrotoxin	Mamba Snake	K⁺ channel	Quantum Dots¹⁰⁴
Conantokin-G	Snail Venom	NMDA receptors		Particles¹⁰⁷
Tetanus toxin	C. tetani	Peripheral nerve polysialogangliosides	Nucleic Acids^145-148 Protein¹⁰⁸, ¹¹⁰^,^149-154	Particles¹⁵⁵ Lipids¹⁴⁵ PEI¹⁴⁸
Hannah toxin	King Cobra Snake	nAchR	Small Molecules131	Micelles¹³¹