Figure 5.

The SPECT/CT image (A), acquired 24 h after injection of ¹¹¹In-IMP288 (185 MBq, 25 μg), pretargeted with 75 mg TF2 (1-day interval), in a 38-year-old patient (cohort 4), shows very clear tumor targeting of an axillary lymph-node metastasis, with very low concentrations of radioactivity in normal tissues. Corresponding contrast-enhanced CT scan and a fused FDG-PET/CT scan are shown [(B,C), respectively]. The primary colon tumor (50 cm ab ano) also shows highly specific tumor targeting in the SPECT image (D), confirmed by the CT scan and FDG-PET/CT [(E,F), respectively], with non-specific FDG uptake in the ascending colon. This research was originally published in Schoffelen et al. (52).