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. 2015 Jan 13;8:448. doi: 10.3389/fnins.2014.00448

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Copyright © 2015 Hauser, Hedlund, Roberts, Sari, Bell and Engleman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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This illustration depicts the expression of 5-HT7 receptors in brain structures relevant to addiction. The expression of 5-HT7 receptors has been found within several areas in the mesocorticolimbic dopamine (MCL-DA) reward pathway such as ventral tegmental area (VTA), nucleus accumbens (ACB), amygdala (AMG), hippocampus (HIPP), and prefrontal cortex (PFC). The solids lines represent DA projections from the VTA to the ACB, AMG, HIPP, and PFC. The dotted lines represent 5-HT projections from dorsal raphe nucleus (DRN) to VTA, ACB, AMG, HIPP, and PFC.