Table 2.
Univariate and multivariate cox proportional hazards regression models of the clinical factors associated with recurrence-free survival in preoperative chemoradiotherapy patients with pathologically- proven metastatic lymph nodes
| Factor |
Univariate analysis |
Multivariate analysis |
||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Sex | 0.41 | |||||
| Male | 1.00 | |||||
| Female | 0.85 | 0.57-1.25 | ||||
| Age (yr) | 1.00 | 0.98-1.02 | 0.89 | |||
| Lymphovascular invasion | 0.54 | |||||
| None | 1.00 | |||||
| Present | 1.28 | 0.83-1.98 | ||||
| Perineural invasion | 0.01 | 0.02 | ||||
| None | 1.00 | 1.00 | ||||
| Present | 1.89 | 1.22-2.95 | 1.82 | 1.15-2.87 | ||
| Sphincter preservation | 0.01 | 0.93 | ||||
| No | 1.00 | 1.00 | ||||
| Yes | 0.60 | 0.40-0.89 | 0.96 | 0.35-2.59 | ||
| Tumor grade | 0.34 | |||||
| G1, G2 | 1.00 | |||||
| G3, G4 | 1.31 | 0.75-2.31 | ||||
| Preoperative CEA | 0.45 | |||||
| Normal | 1.00 | |||||
| Increased | 1.22 | 0.73-2.05 | ||||
| Location of tumor | 0.25 | 0.89 | ||||
| Mid-rectum | 1.00 | |||||
| Lower rectum | 1.26 | 0.85-1.87 | 1.03 | 0.66-1.62 | ||
| Number of retrieved lymph node | 0.97 | 0.95-1.01 | 0.14 | |||
| Adjuvant chemotherapy1 | 0.36 | 0.46 | ||||
| Same1 | 1.00 | 1.00 | ||||
| Altered | 0.72 | 0.35-1.47 | 0.76 | 0.36-1.58 | ||
1
Same: same regimen as that used for preoperative concurrent chemoradiotherapy. Altered: Second-line regimen was different from that used for preoperative chemotherapy; CEA: Carcinoembryonic antigen.