Table 3.
Recurrence and associated factors (n = 90)
| No recurred (n = 84) | Recurred (n = 6) | P value | |
| Age (yr) | 57.8 ± 12.0 | 64.8 ± 7.4 | 0.159 |
| Sex | 1.000 | ||
| Male | 52 (61.9) | 4 (66.7) | |
| Female | 32 (38.1) | 2 (33.3) | |
| Depth of invasion | 1.000 | ||
| Mucosa | 12 (14.3) | 0 (0) | |
| Submucosa | 72 (85.7) | 6 (100) | |
| Tumor size (cm) | 4.7 ± 2.5 | 3.7 ± 1.27 | 0.321 |
| Histology | 0.681 | ||
| Differentiated | 44 (52.4) | 4 (66.7) | |
| Undifferentiated | 40 (47.5) | 2 (33.3) | |
| Lauren | 0.396 | ||
| Intestinal | 49 (58.3) | 5 (83.3) | |
| Diffuse, mixed | 35 (41.7) | 1 (16.7) | |
| Lymphovascular invasion | 0.032 | ||
| Absent | 40 (47.6) | 0 (0) | |
| Present | 44 (52.4) | 6 (100) | |
| Metastatic LNs (n) | 2.0 ± 1.3 | 2.2 ± 1.2 | 0.816 |
| Classification of nodal metastasis | 0.041 | ||
| Micrometastasis | 37 (44.0) | 0 (0) | |
| Macrometastasis | 47 (56.0) | 6 (100) | |
| Japanese N2 station involvement1 | 0.127 | ||
| No | 58 (85.3) | 2 (50.0) | |
| Yes | 10 (14.7) | 2 (50.0) | |
| Main tumor burden in LN (mm) | 3.0 ± 4.1 | 4.0 ± 1.5 | 0.594 |
| Pattern of metastasis in LNs | 0.450 | ||
| Single cluster | 28 (33.3) | 4 (66.7) | |
| Multiple cluster | 54 (64.3) | 1 (16.7) | |
| Diffuse | 2 (2.4) | 1 (16.7) | |
| Location of metastasis in LNs | 0.090 | ||
| Marginal sinus | 31 (36.9) | 0 (0) | |
| Non marginal sinus | 53 (63.1) | 6 (100) | |
| Gastric resection | 1.000 | ||
| Open subtotal | 63 (75.0) | 4 (66.7) | |
| Open total | 7 (8.3) | 1 (16.7) | |
| LADG | 14 (16.7) | 1 (16.7) | |
| Lymph node dissection | 1.000 | ||
| D1 + β | 28 (33.3) | 2 (33.3) | |
| D2 | 56 (66.7) | 4 (66.7) | |
| Dissected LNs (n) | 37.4 ± 13.8 | 41.0 ± 16.4 | 0.538 |
| Adjuvant chemotherapy | 0.660 | ||
| No | 30 (35.7) | 1 (16.7) | |
| Yes | 54 (64.3) | 5 (83.3) | |
| Ki-67 (primary tumor)1 | |||
| Positive cell | 61.3% ± 22.1% | 58.3% ± 24.6% | 0.748 |
| TUNEL (primary tumor)1 | |||
| Positive cell | 3.6% ± 3.9% | 4.6% ± 2.2% | 0.552 |
| Ki-67 (lymph node)1 | |||
| Positive cell | 35.0% ± 23.5% | 35.0% ± 10.8% | 0.996 |
| TUNEL (lymph node)1 | |||
| Positive cell | 2.3% ± 3.2% | 2.8% ± 1.1% | 0.720 |
1
Available data only. Data are expressed as absolute numbers (percentage) or mean ± SD. LN: Lymph node; LADG: Laparoscopically assisted distal gastrectomy; TUNEL: Terminal deoxynucleotidyl transferase dUTP nick end labeling.