Table 2.
Percentage Difference in Bone Outcomes at 60 to 64 Years Old for a 1 SD Increase in Birth Weight
| Men | Women | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | % Difference (95% CI), unadjusted | p | % Difference (95% CI), adjusted for current height and weight | p | % Difference (95% CI), unadjusted | p | % Difference (95% CI), adjusted for current height and weight | p | |
| pQCT diaphyseal radius (50%) site | |||||||||
| 50% radius | |||||||||
| Diaphysis CSA (mm2) | 1349 | 2.90 (1.76, 4.05) | <0.001 | 1.43 (0.33, 2.53) | 0.011 | 2.68 (1.55, 3.82) | <0.001 | 1.33 (0.27, 2.40) | 0.014 |
| Medullary CSA (mm2) | 1348 | 3.77 (1.04, 6.50) | 0.007 | 1.79 (–0.99, 4.57) | 0.206 | 3.09 (0.22, 5.96) | 0.035 | 1.24 (–1.63, 4.11) | 0.395 |
| Polar stress strain index (mm3) | 1350 | 3.94 (2.31, 5.57) | <0.001 | 1.83 (0.26, 3.40) | 0.022 | 3.78 (2.19, 5.36) | <0.001 | 1.99 (0.51, 3.49) | 0.009 |
| pQCT distal radius (4%) site | |||||||||
| Distal CSA (mm2) | 1340 | 2.62 (0.94, 4.29) | 0.002 | 1.55 (–0.16, 3.26) | 0.076 | 2.89 (1.39, 4.38) | <0.001 | 1.38 (–0.06, 2.82) | 0.061 |
| pQCT diaphyseal radius (50%) site | |||||||||
| Cortical vBMD (mg/cm3) | 1350 | –0.02 (–0.26, 0.22) | 0.865 | –0.01 (–0.26, 0.24) | 0.932 | –0.18 (–0.46, 0.09) | 0.196 | –0.20 (–0.48, 0.08) | 0.166 |
| pQCT distal radius (4%) site | |||||||||
| Trabecular vBMD (mg/cm3) | 1340 | –0.81 (–2.55, 0.93) | 0.359 | –0.64 (–2.44, 1.15) | 0.481 | –1.78 (–3.88, 0.33) | 0.098 | –1.36 (–3.49, 0.77) | 0.211 |
| Total vBMD (mg/cm3) | 1340 | –1.49 (–2.87, –0.11) | 0.035 | –1.46 (–2.90, –0.03) | 0.045 | –1.31 (–3.04, 0.42) | 0.137 | –0.88 (–2.62, 0.86) | 0.322 |
| DXA aBMD(g/cm2) | |||||||||
| Spine L1–L4 aBMD (g/cm2) | 1646 | 1.17 (–0.13, 2.47) | 0.077 | 0.19 (–1.09, 1.47) | 0.773 | –0.18 (–1.44, 1.07) | 0.774 | –0.82 (–2.04, 0.40) | 0.188 |
| Hip aBMD (g/cm2) | 1631 | 0.99 (–0.11, 2.08) | 0.077 | –0.07 (–1.07, 0.94) | 0.895 | 0.22 (–0.89, 1.32) | 0.698 | –0.47 (–1.44, 0.50) | 0.340 |
| SA-BMC(g/cm2) | |||||||||
| Spine | 1646 | 0.34 (–0.77, 1.45) | 0.552 | 0.20 (–0.89, 1.28) | 0.719 | –0.60 (–1.73, 0.53) | 0.297 | –0.83 (–1.93, 0.26) | 0.137 |
| Hip | 1631 | 0.54 (–0.48, 1.57) | 0.297 | 0.12 (–0.78, 1.03) | 0.787 | –0.08 (1.11, 0.94) | 0.873 | –0.39 (–1.28, 0.50) | 0.387 |
Unadjusted and adjusted for standardized height and weight at 60 to 64 years of age.
CI = confidence interval; CSA = cross-sectional area; vBMD = volumetric bone mineral density; DXA = dual-energy X-ray absorptiometry; aBMD = areal bone mineral density; SA-BMC = size-adjusted bone mineral content.