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. 2014 Oct 31;6(3):e949195. doi: 10.4161/19382014.2014.949195

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Gerardo J Félix-Martínez and J Rafael Godínez-Fernández

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 7. — Intrinsic metabolic oscillations (DOM model). (A) Diagram of the DOM model. The interactions between glycolytic, metabolic, and electrical components drive different electrical behaviors (simulations shown in B–D) depending on the regime of the glycolytic and electrical components. Glucose is metabolized by the glycolytic and metabolic components controlling the production of ATP, which mediate the changes in the conductance of the K_ATP channels, depolarization, and Ca²⁺ influx. The 3 compartments (glycolytic, electrical, and metabolic) are affected by the changes in [Ca²⁺]_i. (B) Slow bursting is produced entirely by oscillatory glycolysis. (C) Fast bursting produced by the electrical component. (D) The combination of glycolytic and electrical components produces compound bursting activity. (B–D) Top: V_m (black curve) and the state of glycolysis (represented by F6P, orange curve). Bottom: [Ca²⁺]_i (yellow curve) and [ATP]_i (green curve).