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. 2014 Dec 10;35(2):349–357. doi: 10.3892/ijmm.2014.2032

Figure 6.

Figure 6

NF-κB mediates migration towards SDF-1α in the SH-SY5Y cells. SH-SY5Y cells pretreated or untreated with TNF-α (20 ng/ml) for 24 h were seeded in the migration chambers in the presence or absence of PDTC (50 μM) and placed into wells in the presence or absence of SDF-1α (100 ng/ml). The cells were allowed to migrate for 24 h. Representative figures indicate the average number of migrated cells per field. (A) Untreated control. (B) TNF-α pretreated group. (C) Untreated control, SDF-1α-exposed group. (D) TNF-α pretreated, SDF-1α-exposed group. (E) PDTC pretreated group, SDF-1α-exposed group. (F) TNF-α, PDTC pretreated, SDF-1α-exposed group. (G) Migration ability for the different treatments. Results are representative of five independent experiments. *P<0.05 vs. TNF-α pretreated group; **P<0.05 vs. untreated, SDF-1α exposed group; #P<0.05 vs. TNF-α pretreated, SDF-1α exposed group. NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α; SDF-1α, stromal cell-derived factor-1α; PDTC, pyrrolidinedithiocarbamic acid ammonium salt.