Figure 1.

Anticancer effect of GIFT4-stimulated B cells. Granulocyte macrophage colony stimulating factor (GM-CSF) and common γ chain Interleukins Fusion Transgenes (GIFT) fusokines display immunostimulatory phenotypes. GIFT4 (GM-CSF and IL-4 fusion) stimulation converts naïve B cells into effector cells. GIFT4-programmed B cells (GIFT4-B cells) express co-stimulatory molecules, and secrete T cell-driving cytokines and chemokines, thus priming T cells to become cytotoxic and capable of killing tumor cells.