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. 2014 Jul 3;3(7):e944047. doi: 10.4161/21624011.2014.944047

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© 2014 Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Failure of autophagy-deficient melanomas to respond to chemotherapy. Melanomas were induced by adding tamoxifen on the shaved back of mice with the Tyr::CreERT2;Pten^fl/fl;BRaf^CA/+;Atg7^fl/fl genotype. Once the tumors had reached a surface of approximately 100 mm² (day 0), melanomas were treated by intraperitoneal injections of mitoxantrone (MTX) or vehicle (PBS) every 2 weeks, starting on day 0. Tumor growth was monitored with a caliper for 8 weeks. To assess the impact of the cellular immune system, mice were treated i.p. with PBS (A) or a mix of αCD4 and αCD8 antibodies (B) at different times days −3, 0, 1, 3, 5, 8, 15, 22, 29, 36, 43, 50). Experiments were done on 15 mice per group. Results are reported as means ± SEM. *p < 0.05 (unpaired Student's t test).