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. 2014 Jul 3;3(7):e944047. doi: 10.4161/21624011.2014.944047

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© 2014 Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Mitoxantrone reduces the growth of autophagy-competent melanomas in mice with an intact immune system. Once the melanomas from Tyr::CreERT2;Pten^fl/fl;BRaf^CA/+;Atg7^+/+ mice had reached a surface of approximately 100 mm² (day 0), they were treated by intraperitoneal injections of MTX or vehicle (PBS) every 2 weeks. Tumor growth was monitored by means of a caliper for 8 weeks. Additionally, to assess the involvement of the immune system, mice were treated i.p. with PBS (A) or a mix of αCD4 and αCD8 antibodies (B) at different times (days −3, 0, 1, 3, 5, 8, 15, 22, 29, 36, 43, 50). Experiments were done on groups of 15 mice. Results are reported as means ± SEM. *p < 0.05 (unpaired Student's t test).