Table 4.
The reported LATS1 SNPs/variants that were mapped to the TF-binding regions predicted by Transfac database (Kel et al., 2003; Matys et al., 2006).
| SNP/variant consensus position | SNP/variant position | CpG_island | TF type | TFBS consensus sequence within LATS1 | Mutated sequence |
|---|---|---|---|---|---|
| 32 | 5′UTR (exon 1) | CpG_island | |||
| 100 | 5′UTR (exon 1) | CpG_island | GEN_INI | (96) cccCAGTC | cccCgGTC |
| 245 | 5′UTR (exon 1) | CpG_island | |||
| 342 | 5′UTR (exon 1) | CpG_island | AP-2alphaA | (336) acGGACTctggccgc | acGGACactggccgc |
| 439 | 5′UTR (exon 1) | CpG_island | ZNF263 | (438) ctCCTCC | caCCTCC |
| 450 | 5′UTR (exon 1) | CpG_island | p53 | (446) gtgCTCGAgttggcggggcg | gtgCaCGAgttggcggggcg |
| ZF5 | (441) ctccagtGCTCGag | ctccagtGCaCGag | |||
| 515 | 5′UTR (exon 1) | CpG_island | |||
| 15943 | Intron 1 | Myogenin | (15942) CtgCTG | CAgCTG | |
| 16045 | 5′UTR (exon 2) | CDP CR1 | (16043) aggaTCATTt | agcaTCATTt | |
| Nanog | (16043) aggaTCATTttc | agcaTCATTttc | |||
| 22891 | Intron 2 | HNF-3beta | (22891) tacAAACAg | cacAAACAg | |
| 22899 | Intron 2 | FAC1 | (22894) aaacAGAACattaa | aaacAcAACattaa | |
| GR | (22897) cAGAACattaatatca | cAcAACattaatatca | |||
| 35366 | Intron 4 | ardi5a | (35362) tcAATATttattca | tcAAgATttattca | |
| Zfp105 | (35357) gtattTCAATatttatt | gtattTCAAGatttatt | |||
| 41346 | Intron 6 | Xvent-1 | (41344) cagAAAATaggct | caaAAAATaggct | |
| 42029 | Intron 6 | SREBP | (42023) gaatTCtCACAaa | gaatTCACACAaa | |
| RBP-Jkappa | (42025) atTCTCAcaaa | atTCACAcaaa | |||
| 56976 | Exon 8, 3′UTR | SF-1 | (56966) ctcataaCCTTGtt | ctcataaCCTcGtt | |
| Nanog | (56967) tcataacCTTGTttttggta | tcataacCTcGTttttggta | |||
| RUSH-1alpha | (56971) aacCTTGTtt | aacCTcGTtt | |||
| FAC1 | (56972) accttGTTTTtggt | acctcGTTTTtggt | |||
| SOX10 | (56973) cCTTGTt | cCTcGTt | |||
| SRY | (56975) TTGTTt | TcGTTt | |||
| 57142 | Exon 8, 3′UTR | RREB-1 | (57137) cCCCCAccccccgc | cCCCCcccccccgccc | |
| Sp1 | (57137) cccCCACCcc | cCCcCCcc | |||
| RREB-1 | (57138) cCCCACcccccgcc | cCCCcCcccccgcc | |||
| GKLF | (57140) CCACCcc | CCcCCcc | |||
| 57149 | Exon 8, 3′UTR | Churchill | (57144) cCCCCG | cCCCCc | |
| Sp1 | (57144) cccCCGCCcc | cccCCcCCcc | |||
| GKLF | (57147) CCGCCcc | CCcCCcc | |||
| CPBP | (57149) GCCCCat | cCCCCat |
Bold letters indicate locations of the variants.
The upper case letters indicate highly conserved core binding sequence of the TFs.