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. 2015 Jan 13;5:473. doi: 10.3389/fgene.2014.00473

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Copyright © 2015 Lau and Csankovszki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular mechanisms of condensin activity. The proposed mechanisms by which condensin generates and maintains chromosome condensation in interphase and mitosis. Condensin’s structural maintenance of chromosomes (SMC) proteins can reanneal complementary ssDNAs into dsDNAs, in preparation for subsequent coiling steps. Condensin can also introduce ATP-dependent positive supercoils into DNA in vitro. Alternatively, or in addition, condensin is proposed to entrap the chromatin fibers in its ring-like structure.