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. Author manuscript; available in PMC: 2015 Jan 13.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2013 Apr 25;40(4):437–449. doi: 10.1007/s10928-013-9317-1

Fig. 3.

Fig. 3

Observed and PBPK model-simulated docetaxel concentrations in mouse lung, kidney, heart, liver, intestine, plasma and brain and model-predicted intestinal and hepatic metabolism following an intravenous dose of 3 mg/kg. Black diamonds represent the observed data from FVB mice. White diamonds represent the observed data from Mdr1a/b knockout (KO) mice. For all observed data, error bars symbolize SD. Solid lines and dashed lines indicate PBPK model predictions for FVB and KO mice, respectively