Fig. 4.

Calculated sensitivity coefficients for PBPK model parameters with respect to plasma area under the concentration–time curve (AUC) for the FVB mouse model. Only parameters with sensitivity coefficients >0.01 are shown. FQ_KID fractional blood flow to kidney, FV_INT fractional volume of intestine, FV_BLD fractional volume of blood, K_LMET first-order rate constant for hepatic metabolism, KMT Michaelis–Menten constant (Km) for ABCB1 transport, VMAXT_KID maximum rate (Vmax) of ABCB1 transport from kidney, FV_KID fractional volume of kidney, FU unbound fraction of docetaxel in the blood, FQ_INT fractional blood flow to intestine