Table 1.
Sample | Observed FVB AUC1–12 h (nM × h) |
Predicted FVB AUC1–12 h (nM × h) |
Observed KO AUC1–12 h (nM × h) |
Predicted KO AUC1–12 h (nM × h) |
% Difference between observed FVB AUC and observed KO AUCa |
% Difference between observed FVB AUC and predicted FVB AUCb |
% Difference between observed KO AUC and predicted KO AUCc |
---|---|---|---|---|---|---|---|
Lung | 18,866 | 17,368 | 43,833 | 46,082 | +132 % | −7.9 % | +5.1 % |
Kidney | 14,497 | 15,408 | 20,665 | 20,514 | +43 % | +6.3 % | −0.7 % |
Heart | 12,952 | 11,483 | 18,895 | 19,442 | +46 % | −11.3 % | +2.9 % |
Liver | 4,344 | 3,969 | 4,605 | 4,741 | +6 % | −8.6 % | +3.0 % |
Intestine | 3,214 | 3,113 | 7,648 | 7,665 | +138 % | −3.1 % | +0.2 % |
Plasma | 523 | 508 | 481 | 552 | −8 % | −2.9 % | +14.8 % |
Brain | 184 | 176 | 1,001 | 1,149 | +444 % | −4.3 % | +14.8 % |
AUC1–12 h area under the concentration–time curve from 1 to 12 h
Percent (%) difference was calculated as 100 × ((KOAUCobserved − FVBAUCobserved)/(FVBAUCobserved))
Percent (%) difference was calculated as 100 × ((FVBAUCpredicted − FVBAUCobserved)/(FVBAUCobserved))
Percent (%) difference was calculated as 100 × ((KOAUCpredicted − KOAUCobserved)/(KOAUCobserved))