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. Author manuscript; available in PMC: 2015 Jan 13.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2013 Apr 25;40(4):437–449. doi: 10.1007/s10928-013-9317-1

Table 1.

Comparison of docetaxel exposure (AUC) in FVB and Mdr1a/b knockout (KO) mice

Sample Observed
FVB
AUC1–12 h
(nM × h)
Predicted
FVB
AUC1–12 h
(nM × h)
Observed
KO
AUC1–12 h
(nM × h)
Predicted
KO
AUC1–12 h
(nM × h)
% Difference between
observed FVB AUC
and observed KO
AUCa
% Difference between
observed FVB AUC
and predicted FVB
AUCb
% Difference between
observed KO AUC
and predicted KO
AUCc
Lung 18,866 17,368 43,833 46,082 +132 % −7.9 % +5.1 %
Kidney 14,497 15,408 20,665 20,514 +43 % +6.3 % −0.7 %
Heart 12,952 11,483 18,895 19,442 +46 % −11.3 % +2.9 %
Liver 4,344 3,969 4,605 4,741 +6 % −8.6 % +3.0 %
Intestine 3,214 3,113 7,648 7,665 +138 % −3.1 % +0.2 %
Plasma 523 508 481 552 −8 % −2.9 % +14.8 %
Brain 184 176 1,001 1,149 +444 % −4.3 % +14.8 %

AUC1–12 h area under the concentration–time curve from 1 to 12 h

a

Percent (%) difference was calculated as 100 × ((KOAUCobservedFVBAUCobserved)/(FVBAUCobserved))

b

Percent (%) difference was calculated as 100 × ((FVBAUCpredictedFVBAUCobserved)/(FVBAUCobserved))

c

Percent (%) difference was calculated as 100 × ((KOAUCpredictedKOAUCobserved)/(KOAUCobserved))