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. 2014 Jul 17;58(1):183–196. doi: 10.1021/jm500480k

Figure 5.

Figure 5

Evaluation of the ability of compounds to inhibit IL-1α, LPS, or CL097-induced phosphorylation of p105, p38, and JNK in several cell types. (a–c) 293 IL-1R, MEFs, and RAW cells were pretreated with 1 at different concentrations for 1 h and then stimulated with IL-1α or LPS for 30 min. Samples were collected and subjected to Western blot for phosphorylation of p105, p38, JNK1/2, and total p38. (d) Gen2.2 cells were pretreated with 1, S1, and 16 at 1 μM for 1 h and then stimulated with CL097 for 30 min. Samples were collected and subjected to Western blot.