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. 2014 Dec 12;9:56. doi: 10.1186/1750-1326-9-56

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© Rossi et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Role of p53-IL-1β interaction on neuronal damage. A. The graphs show that time-dependent cell swelling was significantly more pronounced in slices incubated with IL-1β than in control conditions (p < 0.05) and that this effect was attenuated by CNQX (p > 0.05), a glutamate AMPA receptor antagonist, and PFT (p > 0.05). B. Examples of neuronal swelling induced by IL-1β in the presence or absence of PFT. Individual neurons were visualized in situ using a differential interference contrast optical system. C. p21 protein levels were determined in total protein extracts (300 μg) of mouse corticostriatal slices untreated or treated with IL-1β by Western blot analysis. Each lane represents a different animal and is composed by a triplicate experiment performed on the same animal. Densitometric analysis of each lane was calculated using Image J software and data were normalized to actin used as loading control. IL-1β significantly increases the expression of p21 protein. *means p < 0.05.