Table 2.

p values for p53 gene/IL-1β interaction effects

	TP53 genotype	dominant model	recessive model
PI	0.002	0.73	0.01
MSSS	0.02	0.30	0.02
MV	0.04	0.16	0.03
RNFL thickness	0.01	0.02	0.005

PI, progression index; MSSS, Multiple Sclerosis Severity Scale; MV, macular volume; RNFL, retinal nerve fiber layer. Although our sample was too small to test other statistical associations, higher values of both PI and MSSS were present in Arg/Arg carriers among patients with undetectable IL-1β (PI: Pro/Pro 0.16 +/- 0.13, Arg/Pro 0.14 +/- 0.09, Arg/Arg 0.21 +/- 0.17; MSSS: Pro/Pro 1.73 +/- 1.62, Arg/Pro 1.73 +/- 1.68, Arg/Arg 2.61 +/- 2.33).