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. 2014 Aug 30;16(4):419. doi: 10.1186/s13075-014-0419-y

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© Greenhill et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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IL-10KO mice have enhanced and prolonged antigen-induced arthritis (AIA). Disease activity in AIA challenged WT (closed circles) and IL-10KO (open circles) mice. (A) Joint swelling, (B) arthritic index scores and (C) synovial inflammation are shown. Swelling data reflects the mean ± SEM of knee diameters (in mm; n = 7-28, ^* P <0.05). Arthritic index and synovial inflammation values post AIA are presented for individual joints taken at days 3, 14, 28 and 35 (data is presented as the mean ± SEM, n = 5-7 per time point from a single experiment, ^* P <0.05, ^** P <0.01 between WT and IL-10KO groups). IL-10KO, interleukin-10-deficient; WT, wild-type.

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