Table 3.
Additional ECM Proteins
| Gene Name |
MW. | ID. Count | Avg. Sequence Coverage |
Avg. Unique Peptides |
Norm. Spectral Intensity |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rank | Accession | Protein name | (kDa) | N | I | IIb | N | I | IIb | N | I | IIb | I/N | IIb/I | |
| 260 | IPI00202515 | ADIPOQ | Adiponectin | 26 | 4 | 4 | 4 | 15% | 15% | 17% | 3 | 3 | 3 | 0.71 ** | 0.69 * |
| 119 | IPI00562438^ | AGRN | Agrin | 198 | 4 | 4 | 4 | 3% | 8% | 7% | 3 | 13 | 12 | 29.10 * | 0.91 |
| 394 | IPI00554123 | AGRN’ | Agrin’ | 104 | 0 | 4 | 4 | - | 12% | 12% | - | 3 | 3 | Up | 2.57 |
| 160 | IPI00365784 | BGN | Asporin | 43 | 4 | 4 | 4 | 17% | 16% | 26% | 6 | 5 | 8 | 0.69 | 1.81 |
| 55 | IPI00191090 | BMPG | Biglycan | 42 | 4 | 4 | 4 | 21% | 24% | 21% | 7 | 8 | 8 | 1.13 | 0.92 |
| 19 | IPI00199861 | DCN | Decorin | 40 | 4 | 4 | 4 | 37% | 39% | 37% | 18 | 16 | 16 | 0.57 * | 1.11 |
| 108 | IPI00371512 | DPT | Dermatopontin | 24 | 4 | 4 | 4 | 26% | 22% | 24% | 6 | 5 | 5 | 0.32 | 0.92 |
| 734 | IPI00199867 | EMILIN1 | Elastin microfibril interfacer 1 | 95 | 3 | 4 | 3 | 1% | 2% | 1% | 2 | 2 | 1 | 0.97 | 0.49 |
| 20 | IPI00951429 | FBN1 | Fibrillin 1 | 312 | 4 | 4 | 4 | 31% | 26% | 23% | 67 | 55 | 50 | 0.48 ** | 1.09 |
| 13 | IPI00231984 | FN1 | Fibronectin 1 | 260 | 4 | 4 | 4 | 19% | 18% | 15% | 45 | 40 | 39 | 0.59 *** | 0.87 |
| 674 | IPI00358887 | FNDC1 | Fibronectin type II I domain-CP1 | 194 | 2 | 4 | 4 | 1% | 1% | 1% | 1 | 1 | 1 | 1.94 | 1.23 |
| 635 | IPI00370411 | FBLN1 | Fibulin-1 | 78 | 3 | 3 | 4 | 3% | 6% | 2% | 1 | 2 | 1 | 1.99 | 0.58 |
| 303 | IPI00365178^ | FBLN2 | Fibulin-2 | 126 | 4 | 4 | 4 | 2% | 4% | 4% | 1 | 3 | 3 | 5.91 * | 0.93 |
| 337 | IPI00365221^ | EFEMP1 | Fibulin-3 | 55 | 4 | 4 | 4 | 3% | 8% | 5% | 1 | 3 | 2 | 9.14 *** | 0.88 |
| 165 | IPI00326179 | FBLN5 | Fibulin-5 | 50 | 4 | 4 | 4 | 12% | 12% | 15% | 4 | 5 | 5 | 2.95 | 0.97 |
| 182 | IPI00231275 | LGALS1 | Galectin-1 | 15 | 3 | 3 | 3 | 19% | 23% | 33% | 3 | 4 | 5 | 0.97 | 1.12 |
| 146 | IPI00194341 | LGALS3 | Galectin-3 | 27 | 4 | 4 | 4 | 13% | 18% | 21% | 2 | 5 | 5 | 7.13 | 1.26 |
| 842 | IPI00199448 | LGALS3BP | Galectin-3-binding protein | 64 | 0 | 4 | 0 | - | 4% | - | - | 1 | - | Up | Down |
| 25 | IPI00206403 | LUM | Lumican | 38 | 4 | 4 | 4 | 33% | 36% | 36% | 10 | 11 | 11 | 1.09 | 0.85 |
| 494 | IPI00211401 | MGP | Matrix Gla protein | 12 | 3 | 3 | 3 | 11% | 15% | 11% | 1 | 1 | 1 | 3.55 | 0.63 |
| 47 | IPI00231136 | NID1 | Nidogen-1 | 137 | 4 | 4 | 4 | 14% | 18% | 16% | 19 | 18 | 19 | 1.00 | 1.01 |
| 81 | IPI00372786 | NID2 | Nidogen-2 | 153 | 4 | 4 | 4 | 6% | 8% | 4% | 13 | 10 | 9 | 0.73 | 0.71 |
| 51 | IPI00362931 | OGN | Osteoglycin | 34 | 4 | 4 | 4 | 18% | 16% | 17% | 11 | 9 | 9 | 0.77 | 0.78 |
| 569 | IPI00327895^ | SPP1 | Osteopontin | 35 | 0 | 4 | 2 | - | 9% | 5% | - | 2 | 2 | Up | 0.33 |
| 18 | IPI00193018^ | POSTN | periostin | 90 | 4 | 4 | 4 | 40% | 36% | 39% | 29 | 26 | 25 | 0.43 ** | 1.17 |
| 63 | IPI00210360 | HSPG | Perlecan | 394 | 4 | 4 | 4 | 19% | 18% | 17% | 9 | 9 | 10 | 0.88 | 0.88 |
| 10 | IPI01016479 | HSPG2 | Perlecan-2 | 375 | 4 | 4 | 4 | 18% | 17% | 17% | 58 | 52 | 53 | 0.76 | 0.86 |
| 31 | IPI00190287 | PRELP | Prolargin | 43 | 4 | 4 | 4 | 29% | 31% | 32% | 12 | 12 | 12 | 0.83 | 0.94 |
| 457 | IPI00207123 | TNC | Tenascin-C | 222 | 0 | 4 | 4 | - | 4% | 1% | - | 7 | 2 | Up *** | 0.23 *** |
| 95 | IPI00911228 | TNXB | Tenascin-X | 127 | 4 | 4 | 4 | 15% | 6% | 10% | 17 | 7 | 11 | 0.14 *** | 4.93 |
| 343 | IPI00948911 | TNXB’ | Tenascin-X’ | 23 | 4 | 4 | 4 | 17% | 11% | 11% | 2 | 1 | 1 | 0.37 ** | 0.63 |
| 164 | IPI00188622 | TGFBI | TGF, beta induced | 75 | 4 | 4 | 4 | 16% | 15% | 17% | 10 | 8 | 9 | 0.73 | 1.17 |
| 284 | IPI00471665^ | VWA1 | VEF A domain-cont. protein 1 | 45 | 4 | 4 | 4 | 10% | 12% | 14% | 2 | 4 | 4 | 1.90 | 1.04 |
^
() peptides match to additional IPI entries (same protein group)
’
() protein isoform
*
() P < 0.05
**
() P < 0.01
***
() P < 0.001
ID Count=number of runs, out of the four experiments, in which a protein was identified. Norm. Spectral Intensity=summed intensity of MS/MS product ions for all spectra mapped to a given protein normalized by molecular weight.