Table 1.
Summary of non-synonymous μ-opioid receptor variants in the protein coding region, their corresponding OPRM1 SNP, exon and μ-opioid receptor protein domain
| AA exchange | μ-Opioid receptor domain | SNP | Exon |
|---|---|---|---|
| N40D | N-terminus | 118 A > G | 1 |
| A6V | N-terminus | 17 C > T | 1 |
| S42C | N-terminus | 124 T > A | 1 |
| D51N | N-terminus | 151 G > A | 1 |
| G63V | N-terminus | 188 G > T | 1 |
| S66F | N-terminus | 197 C > T | 1 |
| L85I | TM1 | 253 C > A | 1 |
| S147C | TM3 | 440 C > G | 2 |
| N152D | TM3 | 454 C > G | 2 |
| R181C | ICL2 | 541 C > T | 2 |
| N190K | ICL2 | 570 A > T | 2 |
| C192F | TM4 | 575 G > T | 2 |
| R260H | ICL3 | 779 G > A | 3 |
| R265H | ICL3 | 794 G > A | 3 |
| S268P | ICL3 | 802 T > C | 3 |
| D274N | ICL3 | 820 G > A | 3 |
| V293A | TM6 | 877 G > A | 3 |
See references in the text for original reports.