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. 2014 Jul 1;172(2):435–448. doi: 10.1111/bph.12705

Figure 3.

Figure 3

The relationship between maximal cAMP inhibition and internalization elicited by δ opioid receptor ligands is not proportional. HEK293 cells expressing δ opioid receptor-Flag were treated with maximal effective concentrations (10 μM) of the indicated ligands, and cAMP inhibition (n = 6–9) or receptor internalization (n = 9–12) were assessed using a radiometric or an ELISA-based assay. Data were fit to a single site hyperbola and goodness of fit is indicated in the figure. (Modified with permission from Charfi et al., 2013).