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Tapentadol potentiates responses of LC neurons to noradrenaline. (A). Typical recording showing that tapentadol in the continuous presence of noradrenaline enhances the outward current induced by noradrenaline (INA) via inhibiting the noradrenaline reuptake transporter (NAT). In these experiments, the μ receptors were blocked by naloxone (1 μM). (B). Concentration-response curve for enhancement of the noradrenaline current (INA) by tapentadol (IC50 = 2.3 μM).
