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. 2014 Jul 1;172(2):501–514. doi: 10.1111/bph.12687

Figure 1.

Figure 1

The δ-opioid receptor reduces the expression of desmogleins 1 and 4. (A) Representative images of DSG1 and DSG4 immnunofluorescence staining of non-wounded epidermis from WT and DOPr–/– mice. Scale bar 20 μm. (B) Quantification of DSG1 and DSG4 fluorescence intensity at the epidermis (region of interest). Results are represented as mean ± SEM of 4 mice per group and 5 images per individual mouse (n = 20). (c) Quantitative real-time PCR measured expression of DSG1 and DSG4 mRNA in DOPr-OE N/TERT-1 cells treated with Met-Enk for 12 h (+/− antagonist NTI 15 min prior to Met-Enk). Values are normalized to respective DMSO controls and represent the mean ± SEM of one representative experiment. One-way anova with Newman–Keuls post hoc test, *P ≤ 0.05.