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SNL induced mechanical allodynia, but sham operation did not alter mechanical paw withdrawal pressure at any time points tested from days 1 to 19. (A) Time course of paw withdrawal pressure and (B) corresponding AUC from days −1 to 19. (C) An example of AUC determination. Data shown are means ± SEM. ***P < 0.001, significantly different from sham-saline group; Student's t-test.
