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Morphine, but not naltrexone induced rewarding effects in mice that had been transfected with MOR-S196ACSTA in the spinal cord and with SNL. Data are expressed as preference for the drug-paired compartment as determined by time spent in the drug-paired compartment minus time spent in the saline-paired compartment. Data are presented as mean ± SEM (n = 8). ***P < 0.001, significantly different from preconditioning test on day 5; Student's paired t-test.
