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. 2014 Nov 24;172(2):642–653. doi: 10.1111/bph.12774

Figure 5.

Figure 5

Variation in DOP receptor agonist structure corresponds to outcome of intrathecal co-delivery with morphine. Table illustrates outcomes of morphine delivered in combination with each DOP receptor agonist in PKCε-WT and PKCε-KO. ‘Syn’ or ‘Add’ indicates a synergistic or additive interaction respectively as determined by isobolographic analysis. Interaction index values are given in parentheses as a secondary measure of synergism (or lack thereof). A value of 1 indicates pure additivity. Increasing distance of values from 1, either above or below, indicates departure from additivity, towards either antagonism or synergism respectively. Morphine structure is illustrated at the top left. Structures for each DOP receptor agonist are shown on the right with coloured highlights indicating specific structural differences between similar agonists yielding opposing outcomes with morphine. For morphine, n = 12 in PKCε-WT and n = 11 in PKCε-KO. For DELT-II, n = 11 in PKCε-WT and n = 12 in PKCε-KO. For all other groups, n = 6 for PKCε-WT and PKCε-KO.