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. 2014 Dec 11;6(12):117. doi: 10.1186/s13073-014-0117-z

Figure 1.

Figure 1

Flowchart of methods. We first identified stage-dependent gene expression alterations, then evaluated the effect of CNV/methylation on expression, and finally built a model to infer stage-dependent activity changes of transcription factors by combining the contributions of CNV/methylation.