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. 2014 Dec 15;5(6):136. doi: 10.1186/scrt526

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© Liu et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Role of p53 in mesenchymal stem cell-induced prevention of hypertrophic scar in the rabbit ear model. Representative (A) general observations (scale bar, 5 mm), (B) hematoxylin and eosin staining (scale bar, 500 μm), (C) Masson’s trichrome staining (scale bar, 200 μm), and (D) immunohistochemistry of CD31 (scale bar, 200 μm) of scar sections 4 weeks after model operation from three individual experiments. (E) Scar elevation index (SEI). (F) Integrated optical density analysis of Masson’s trichrome staining. Data expressed as mean ± standard error of the mean, n = 6. *P <0.05 vs. control (Ctrl) group and p53 shRNA mesenchymal stem cell (MSC) group.