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. 2014 Dec 15;5(6):136. doi: 10.1186/scrt526

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© Liu et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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TβRI and α-SMA of fibroblasts were downregulated by mesenchymal stem cells in a p53-dependent manner. Fibroblasts derived from rabbit ear hypertrophic scar were treated with or without conditioned medium from control shRNA mesenchymal stem cells (MSCs) or p53 shRNA MSCs for 48 hours. The (A) mRNA and (B,C) protein levels of TβRI and α-SMA were determined by real-time PCR and western blot. n = 3, *P <0.05 vs. untreated group, p53 shRNA group. Data shown are representative of three individual experiments. α-SMA, alpha smooth muscle actin; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; TβRI, transforming growth factor-beta receptor 1.