TABLE 1.
CFSs in Order of High to Low Frequency in Epithelial Cells Versus Lymphoblasts and Fibroblasts
| MCF10A | MCF10A FHIT KD | 184A1 | HCT116 | BEAS-2B | GM1500 | Lympho blasts (Mrasek et al., 2010) |
MRC-5 fibroblasts (Letessier et al., 2011) |
Primary Fibroblasts (Murano et al., 1989b) |
|---|---|---|---|---|---|---|---|---|
| 16q23 | 16q23 | 16q23 | 16q23 | 3p14.2 | 16q23 | 3p14.2 | 3q13.3 | 3q26.2 |
| 2q33 | 7q22 | 3q26.2 | 2q33 | 2q33 | 3p14.2 | 16q23.2 | 1p31.1 | 7q11.2 |
| 5q15 | 2q33 | Xq22.1 | 4q21.3 | 16q23 | 4q35 | Xp22.3 | 16q23 | 16q23 |
| Xq22.1 | 9p22 | 12q22 | Xp22.3 | Xq22.1 | 8q22 | 2q32.1 | 2q22 | 1p31 |
| 1q23 | 5q15 | 14q24.3 | Xq22.1 | 13q32 | Xp22.1 | 1p21.3 | 3q28 | 10q11.2 |
| 2q21 | Xq22.1 | 7q11.2 | 7q31.2 | 1p31.2 | 6q25.1 | 6q26 | 3q12 | 12q23 |
| 12q22 | 2q21 | Xp21.2 | 3q25 | 7q31.2 | 1p22 | 7q31.1 | 7q31.1 | 7q31 |
| 1p22 | 1p22 | 13q14.3 | 4p15.2 | 7q11.2 | 9q12 | 7q32.2 | 7q11.2 | |
| 1p31 | 1q44 | 1p31.2 | 3p13 | 22q13 | 2q22 | 1q44 | 3p14.2 | |
| 2q13 | 2q23 | 13q22 | Xp21.2 | 1p22 | 3p25 | 4q31.1 | 13q31 | |
| 0.025 | 0.058 | 0.143 | 0.062 | 0.139 | 0.04 |
Numbers of metaphases analyzed for CFS enumeration in MCF10A, MCF10A FHIT KD, 184A1, HCT116, BEAS2B, and GM1500 is 36, 20, 20, 20, 44, and 20, respectively. Bold numbers in the last row indicate the average number of breaks per chromosome in the epithelial cells versus the lymphoblastoid GM1500 cells.