Table 2. Measures of Disease Aggressiveness by Genotype.
| Genotype | ||||
|---|---|---|---|---|
|
| ||||
| RR (n=104) | RQ (n=101) | QQ (n=27) | P Value | |
|
| ||||
| Clinical Characteristics | ||||
|
| ||||
| Biopsy Gleason score Median | 6 | 6 | 6 | 0.7 |
| OR (95% CI) | 1.0 (ref. group) | 1.04 (0.59-1.86) | 1.26 (0.50-3.15) | |
|
| ||||
| Tumor Stage Median | T1c | T1c | T1c | 0.6 |
| OR (95% CI) | 1.0 (ref.group) | 1.11 (0.53-2.32) | 0.92 (0.31-2.76) | |
|
| ||||
| PSA level at diagnosis Mean (SD) | 6.72 (4.10) | 5.79 (3.00) | 7.30 (6.91) | 0.1 |
|
| ||||
| Risk Group | 0.9 | |||
| % Low | 58 | 61 | 67 | |
| OR (95% CI) | 1.0 (ref. group) | 1.17 (0.67-2.04) | 1.47 (0.60-3.57) | |
|
| ||||
| % Intermediate | 36 | 29 | 30 | |
| OR (95% CI) | 1.0 (ref. group) | 0.73 (0.40-1.31) | 0.76 (0.30-1.91) | |
|
| ||||
| % High | 7 | 6 | 4 | |
| OR (95% CI) | 1.0 (ref. group) | 0.88 (0.28-2.70) | 0.53 (0.06-4.53) | |
|
| ||||
| Pathologic Characteristics | ||||
|
| ||||
| Surgical Gleason Score Median | 7 | 7 | 7 | 0.8 |
| OR (95% CI) | 1.0 (ref. group) | 0.75 (0.42-1.35) | 0.92 (0.35-2.40) | |
|
| ||||
| Tumor volume | 0.02 | |||
| Low | 19 | 19 | 8 | |
| OR (95% CI) | 1.0 (ref. group) | 1.04 (0.51-2.10) | 1.88 (0.72-4.94) | |
|
| ||||
| Medium | 43 | 64 | 10 | |
| OR (95% CI) | 1.0 (ref. group) | 2.45 (1.40-4.31) | 0.83 (0.35-2.00) | |
|
| ||||
| Extensive | 41 | 18 | 9 | |
| OR (95% CI) | 1.0 (ref. group) | 0.33 (0.18-0.63) | 0.77 (0.32-1.87) | |
|
| ||||
| Disease Confinement | 0.6 | |||
| Organ Confined | 55 | 56 | 19 | |
| OR (95% CI) | 1.0 (ref. group) | 1.11 (0.64-1.92) | 2.12 (0.85-5.26) | |
|
| ||||
| Non-organ confined | 49 | 45 | 8 | |
| OR (95% CI) | 1.0 (ref. group) | 0.90 (0.52-1.56) | 0.47 (0.19-1.18) | |