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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Alcohol Clin Exp Res. 2014 Dec;38(12):3033–3042. doi: 10.1111/acer.12588

Figure 4.

Figure 4

Pretreatment with 2 mg/kg of varenicline attenuated the expression of ethanol-induced locomotor sensitization. Shown are means ± SEM distance traveled in cm during the first 5 min of the 15 min activity session. Labels along x-axis show acquisition group and day 13 group (pretreatment + treatment). (A) Ethanol-induced sensitization (day 12 minus day 3) during acquisition is shown in the first 4 bars; change in activity level in saline-group mice during the acquisition period is shown in the remaining bars. (B) Effect of varenicline on ethanol challenge response (first 8 bars) and activity level after saline treatment (last 4 bars); data are corrected for baseline activity level (day 13 minus day 2). SAL = 0.9% saline; VARx = x mg/kg varenicline tartrate. E2 = 2 g/kg ethanol.