Figure 8. A reduction in GABA_BR activity on LC neurons decreases tonic inhibition: chronic perinatal CTM exposure study.

A, representative recordings from an LC neuron in a saline-treated male rat (1–3) and a CTM-treated male rat (1′–3′) showing the SFR at baseline (traces 1 and 1′) and after application of 20 μm BicmBr (traces 2 and 2′) followed by 10 μm CGP54626 (traces 3 and 3′); the numbers refer to the times in the time-course shown in B. B, summarized results showing the entire time-course of the recordings. Note the significant difference in the baseline SFR between the saline- and CTM-treated groups (dashed rectangle). C and D, representative recordings in saline- or CTM-treated female rats (C) and the summarized results (black lines and symbols) (D). Note CTM has no effect on the baseline SFR (dashed rectangle). The continuous and dotted lines (grey) in D are the results (mean ± SEM) for the saline-treated male rats taken from panel B and superimposed for comparison.