FIG. 5.

Effect of diclofenac-sodium-releasing PLGA/PEG scaffolds on nitrite production in the in vitro calvarial osteoblast inflammation model. Nitrite accumulation was measured on days 1, 2, and 7, after scaffold placed in transwell. (A) Nitrite concentration at each timepoint. (B) Cumulative nitrite concentration over 7 days. Statistical significance versus 0 μg/scaffold in osteogenic medium, *p≤0.01. Statistical significance versus 0 μg/scaffold in cytokine medium, ^#p≤0.01. Values represented as mean±standard error of the mean (SEM); experiment repeated in triplicate each with n=3.