. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Hum Genet. 2014 Dec 30;134(2):259–267. doi: 10.1007/s00439-014-1519-0

Table 2.

Variance in T2D risk explained by parental history of diabetes (FH) and known genetic (G1) and environmental (E1) risk factors

Model	NHS^a		HPFS^a

	σ ²	95% CI	σ ²	95% CI
FH	0.069	0.051-0.087	0.062	0.042-0.082
G1	0.032	0.020-0.044	0.031	0.017-0.045
E1	0.179	0.154-0.204	0.185	0.155-0.215
FH, G1	0.093	0.073-0.113	0.084	0.062-0.106
FH, E1	0.222	0.196-0.248	0.226	0.195-0.257
G1, E1	0.207	0.181-0.233	0.212	0.181-0.243
FH, G1, E1	0.244	0.217-0.270	0.247	0.216-0.278

Observed-scaled σ² from linear regressions of FH, G1 (T2D GRS) and E1 (age, BMI, smoking status, diet quality, alcohol consumption and physical activity) and their combinations (specified in column 1) on T2D case-status.