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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2014 Nov 15;22(22):6490–6502. doi: 10.1016/j.bmc.2014.09.019

Figure 1.

Figure 1

(A) Structure of MAL2-11B tetrazole. (B) Compounds in the KRL series were derived specifically from the MAL2-11B tetrazole. These analogs were designed to determine the significance of the biphenyl moiety as well as the length and flexibility of the hydrocarbon linker to the tetrazole group in inhibiting SV40 T Ag ATPase activity. (C) KRL compounds failed to inhibit SV40 T Ag ATPase activity. Steady state ATPase assays were used to quantitate the percent ATP hydrolyzed by T Ag in the presence of the indicated compounds at a final concentration of 100 μM. The average percent activity of the protein is relative to T Ag in the absence of the inhibitor. Data represent the means of three independent experiments, +/− SD.