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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2014 Nov 15;22(22):6490–6502. doi: 10.1016/j.bmc.2014.09.019

Figure 4.

Figure 4

(A) Structure of MAL282-66. (B) Select ML compounds inhibit SV40 T Ag ATPase activtiy. The indicated ML compounds were titrated into a steady state ATPase assay containing T Ag. The average percent activity is relative to T Ag in the absence of inhibitor. Data represent the means of three independent experiments, +/− SD. (C) The LR340 compounds are effective inhibitors of SV40 T Ag ATPase activity. The indicated compounds were titrated into a steady state ATPase assay containing T Ag. The average percent activity of the protein is relative to T Ag in the absence of the inhibitor. Data represent the means of three independent experiments, +/− SD. The final concentrations of the compounds used in these studies were 10, 30, and 100 μM.