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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Neurooncol. 2014 Sep 26;121(1):109–118. doi: 10.1007/s11060-014-1618-8

Fig. 1.

Fig. 1

EphrinB1 is differentially expressed in childhood medulloblastoma (MB).

Representative photomicrographs (40X) for immunohistochemistry of MB tissue demonstrate strong diffuse cytoplasmic and membrane positive immunostaining for EphB1, EphB2, ephrinB2 and ephrinA3. In contrast, positive immunostaining for ephrinB1 is restricted to islands within the tumor comprised of dense neoplastic cells with a higher mitotic proliferative index (far left middle panel). EphrinB1 immunostaining is negative in the less densely cellular neoplastic regions displaying a lower mitotic index within the same tumor (center middle panel) and is negative in normal fetal cerebellum (far right middle panel)