Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Ann Neurol. 2014 Nov 27;77(1):100–113. doi: 10.1002/ana.24306

Table 5.

Gene-based rare variant association tests

Gene P-value # Markers
SOD1 1.59×10−5 4
TARDBP 5.57×10−3 10
VAPB 5.99×10−3 8
SQSTM1 0.126 39
SETX 0.165 125
FUS 0.323 25
DAO 0.425 26
DCTN1 0.443 58
EWSR1 0.450 21
ANG 0.487 9
TAF15 0.573 34
VCP 0.693 5
OPTN 0.765 20
FIG4 0.863 32

Association tests were performed with SKAT using the optimal.adj method and the default linear, weighted kernel, with significance level=3.57×10−3. Only coding variants with minor allele frequencies <1% were included in the analysis. Only subjects of European Ancestry were used from our cohort and controls (self-declared Caucasians compared to EA in ESP6500 and 1000genomesEUR).