Table 1.
Genetic variants in enamel matrix genes
| gene | SNP | chromosome | positiona | MAFb | base change | location / functionality |
|---|---|---|---|---|---|---|
| AMBN | rs17149026 | 4 | 71440940 | 0.0901 | G-T | upstream |
| rs17733915 | 4 | 71447093 | 0.4477 | C-T | upstream | |
| rs7439186 | 4 | 71469604 | 0.0802 | A-G | missense (Ala-Val) | |
| ENAM | rs1967376 | 4 | 71501744 | 0.0877 | C-T | intron |
| rs12640848c | 4 | 71506412 | 0.3729 | A-G | intron | |
| TFIP11 | rs17402286 | 22 | 26894879 | 0.0383 | A-G | synonymous (Leu-Leu) |
| rs6005060 | 22 | 26895736 | 0.0924 | A-T | intron | |
| rs713900 | 22 | 26898242 | 0.0726 | A-G | intron | |
| rs134134 | 22 | 26898891 | 0.1308 | C-T | intron | |
| rs134135 | 22 | 26898962 | 0.1589 | C-G | intron | |
| rs2097470 | 22 | 26904965 | 0.1245 | C-T | intron | |
| rs134145 | 22 | 26909750 | 0.3727 | A-G | upstream | |
| TUFT1 | rs2337359 | 1 | 151495796 | 0.1854 | C-T | upstream |
| rs1045298 | 1 | 151510825 | 0.1370 | C-T | upstream | |
| rs10158855 | 1 | 151515654 | 0.4212 | G-T | intron | |
| rs17640579 | 1 | 151521933 | 0.2228 | A-G | intron | |
| rs16833391 | 1 | 151547253 | 0.1068 | C-T | inton | |
| rs12749d | 1 | 151555741 | 0.1944 | C-T | 3′UTR |
a
based on Build 37
b
MAF = minor allele frequency in the COHRA1 sample
c
this SNP was independently genotyped and tested for association with dental caries experience in a larger sample of IFS subjects (Wang et al. 2012b); the previous study used different genotyping technology and a different statistical approach; a subset of the participants from the previous study was included in the present study
d
this SNP was independently genotyped and tested for association with dental caries in an independent sample of IHS participants (Slayton et al. 2005)