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. 2015 Jan 6;10:305–320. doi: 10.2147/IJN.S73971

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© 2015 Abbad et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Schematic illustration of (A) the core–shell structure of MH-PNs and MH-MNs, and (B) accumulation of nanoparticles in tumor sites through the EPR effect, intracellular trafficking pathway, and synergistic antitumor effect of MH and TPGS.

Notes: Chemical structures of HA-PBCA (a), MH (b), and TPGS (c). The intracellular trafficking pathway includes steps of receptor-meditated cellular internalization, endolysosomal disassembly, and drug release.

Abbreviations: EPR, enhanced permeability and retention; HA-PBCA, hyaluronic acid-poly(butyl cyanoacrylate); IV, intravenous; MH, morin hydrate; MH-MNs, morin hydrate-loaded mixed nanoparticles; MH-PNs, morin hydrate-loaded plain nanoparticles; ROS, reactive oxygen species; TPGS, D-alpha-tocopheryl polyethylene glycol 1000 succinate.