Table 1.
Properties of atorvastatin nanocrystals stabilized by Labrasol® 0.5% (w/w) alone and along with 0.3% (w/w) cationic polymers (CSL, CSM, and CSH) (n=3)
| Formulations | Particle size (nm) | Polydispersity index | Zeta potential (mV) |
|---|---|---|---|
| ATR-L | 551.6±21.5 | 0.321±0.031 | −14.26±1.5 |
| ATR-CSL | 349.9±41.3 | 0.312±0.016 | 21.57±2.1 |
| ATR-CSM | 392.5±27.6 | 0.298±0.018 | 27.21±2.6 |
| ATR-CSH | 439.5±23.9 | 0.267±0.021 | 32.19±2.9 |
Note: Labrasol®; Gattefosse, Saint-Priest Cedex, France.
Abbreviations: ATR, atorvastatin; CS, chitosan; CSL, low molecular weight chitosan; CSM, medium molecular weight chitosan; CSH, high molecular weight chitosan; ATR-L, atorvastatin nanocrystals stabilized by Labrasol® alone.